I've been working on an Fluent API for node which you can get from https://www.npmjs.org/package/fluentnode
It is basically a large number of JS prototype functions (written in coffee-script) which try to simplify node development, improve developer productivity and make the code more readable.
It's still early days, but there are already a good number of APIs in there (and all are covered by UnitTests)
I would love go get some feedback on the current APIs (and other APIs to add)
Reddit thread